MAPT antibody (Isoform 13, N-Term)

Catalog No. ABIN126938

The Mouse Monoclonal anti-MAPT antibody is suitable to detect MAPT in samples from Human. It has been validated for WB, IP and IHC (p).

Quick Overview for MAPT antibody (Isoform 13, N-Term) (ABIN126938)

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MAPT antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: C45

Product Details anti-MAPT Antibody

Binding Specificity: Isoform 13, N-Term

Characteristics: Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, PHF-tau, Neurofibrillary tangle protein,Paired helical filament-tau

Purification: Affinity Purified

Immunogen: Synthetic peptide corresponding to the N-terminus of of the longest isoform of Human Tau.

Isotype: IgG1

Application Details

Application Notes: Western Blot: 1/1000. Immunoprecipitation: 1/500. Immunohistochemistry: 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 50 % Glycerol, 1 % BSA and 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C/-80 °C

Storage Comment: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for MAPT

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Alternative Name: MAPT / tau

Background: Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimers disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK3. This presents the possibility that miscues in GSK3 signaling contribute to the onset of Alzheimers disease.Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau

UniProt: P10636

Pathways: MAPK Signaling, Microtubule Dynamics, M Phase, Regulation of Cell Size