Chemokine (C-C Motif) Receptor 1 (CCR1) antibody

Antigen: Chemokine (C-C Motif) Receptor 1 (CCR1)

Synonyms: CKR1, CD191, CKR-1, HM145, CMKBR1, MIP1aR, SCYAR1

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN127096

Additional Information

Characteristics: Synonyms: C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, CMKBR1, CMKR1, SCYAR1,HM145, LD78 receptor, Macrophage inflammatory protein 1-alpha receptor, MIP1 alphaReceptor, RANTES-R

Alternative name: CD191 / CCR1

Swiss-Prot: P32246

Immunogen: Recombinant human CCR1

Description: Chemokines play an important role in inflammation and are critical for the recruitment ofeffector immune cells to sites of infection. Chemokines activate leukocytes by binding to Gprotein coupled receptors. The ever-growing chemokine receptor subtypes can be dividedinto 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One ofthe CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, andeosinophils and binds the leukocyte chemoattractant and hemopoiesis regulatormacrophage-inflammatory protein (MIP-1), eotaxin, as well as several other relatedchemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophiltrafficking and proliferation.

Specificity: The anti-CCR1 antibody recognizes 42 kDa CCR1 in Western blot analysis. Species: Human, Mouse. Others not tested.

Application Details

Application Notes: Western Blot: 1-4 μg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 0.5 mg/ml

Buffer: PBS containing 50 % glycerol, 1 % BSA, and 0.02 % thimerosal

Storage: Store the antibody undiluted at -20°C or for long term storage (in aliquots) at -70°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Research Area: Chemokines, Receptors

Restrictions: For Research Use only

Images

Western blot analysis of CCR1 in A357 cell lysate.