MAPK8IP1 antibody

Catalog No. ABIN127294

Product Details anti-MAPK8IP1 Antibody

Target: MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPK8IP1 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: The antibody recognizes 78 kDa JIP1.

Purification: Protein A purified

Immunogen: Synthetic peptide from mouse JIP1.

Application Details

Application Notes: Western Blot: 0.5-4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 2 mg/mL

Buffer: PBS containing 0.5 % BSA, 30 % glycerol, and 0.01 % thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C/-80 °C

Storage Comment: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.

Target Details for MAPK8IP1

Target: MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1))

Alternative Name: MAPK8IP1 / JIP1 (MAPK8IP1 Products)

Synonyms: IB1 antibody, JIP-1 antibody, Jip1 antibody, Prkm8ip antibody, Skip antibody, mjip-2a antibody, JIP1 antibody, Jip-1 antibody, Mapk8ip antibody, PRKM8IP antibody, mitogen-activated protein kinase 8 interacting protein 1 antibody, MAPK8IP1 antibody, Mapk8ip1 antibody

Background: JIP1 (JNK-interacting protein-1) is a cytoplasmic protein that possesses an N-terminal JNKbinding domain and a C-terminal SRC homology 3 (SH3) domain. JIP1 selectively bind to JNK, but not to the ERK or p38 MAP kinases. In addition to JNK, JIP1 binds to specific proteins of JNK pathways, including MKK7, MLK3, and DLK, all at separate binding sites. JIP1 has been identified in brain and kidney tissues, whereas JIP2a, JIP2b, and JIP3 are specifically expressed in the brain. Overexpression of JIP1 causes cytoplamic retention of JNK, thereby preventing its nuclear accumulation and the subsequent activation of the JNK pathways, indicating that JIP1 acts as a cytoplasmic anchor for JNK.Synonyms: C-jun-amino-terminal kinase-interacting protein 1, IB1, Islet-brain 1, JIP-1, JNK MAP kinase scaffold protein 1, JNK-interacting protein 1, Mitogen-activated protein kinase 8-interacting protein 1, PRKM8IP

Gene ID: 9479

NCBI Accession: NP_005447

UniProt: Q9UQF2