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BCL2L1 antibody (BCL2-Like 1)

Details for Product anti-BCL2L1 Antibody No. ABIN135021, Supplier: Log in to see
Antigen
  • Bcl(X)L
  • Bcl-X
  • bcl-x
  • bcl-X
  • bcl-x(l)
  • Bcl-xl
  • bcl-xl
  • bcl-XL
  • bcl-xL
  • Bcl-XL
  • BCL-XL
  • Bcl-xL
  • BCL-XL/S
  • bcl-xl/s
  • bcl-xs
  • Bcl-Xs
  • Bcl-xS
  • bcl-xS
  • Bcl2l
  • bcl2l
  • BCL2L
  • BCL2L1
  • BclX
  • Bclx
  • BCLX
  • bclx
  • bclxl
  • BCLXL
  • BCLXS
  • PPP1R52
  • xR11
Alternatives
anti-Human BCL2L1 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human
482
305
278
137
17
8
6
5
5
3
3
2
2
1
Host
Mouse
282
233
4
3
Clonality (Clone)
Monoclonal ()
Conjugate
This BCL2L1 antibody is un-conjugated
24
15
10
9
7
7
6
5
5
5
5
5
5
5
5
5
5
5
2
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
405
192
166
157
146
127
125
96
93
23
7
4
3
3
2
1
1
Supplier
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Immunogen Recombinant Bcl-xS Ig
Clone 7B2-5
Isotype IgG
Characteristics The antibody detects: Human Bcl-xL (Mr 29 kDa)
Mab 7B2.5 recognizes both human and rodent Bcl-xL.
Purification Purified
Alternative Name Bcl-xL (BCL2L1 Antibody Abstract)
Background Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems. It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment. Bcl-2 and one of its homologues, Bcl-xL, protect cells from apoptosis, while other homologues of Bcl-2 such as Bax, Bad and Bak have been shown to enhance apoptosis. Bcl-xL has been shown to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2. In contrast, Bad and Bax inhibit the protective functions of Bcl-xL and Bcl-2, respectively. Although heterodimerization between Bcl-xL/Bad and Bcl-2/Bax was originally thought to be essential for the differential anti-apoptotic activity of Bcl-xL and Bcl-2, other results suggest that the formation of heterodimers may not be necessary for this death-repressing activity.
Research Area Cancer
Pathways Apoptosis
Application Notes Working Dilution:
FACS: 3 µg/10^6 cells
Representative data are included in this product insert.

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Sample Volume 1 mL
Restrictions For Research Use only
Buffer Product is supplied as 0.1 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.0.
Preservative Without preservative
Handling Advice Each reagent is stable for the period shown on the bottle label if stored as directed.
Storage 4 °C
Supplier Images
 image for anti-BCL2L1 antibody (BCL2-Like 1) (ABIN135021) anti-BCL2-Like 1 (BCL2L1) antibody
Product cited in: Gottschalk, Boise, Oltvai, Accavitti, Korsmeyer, Quintáns, Thompson: "The ability of Bcl-x(L) and Bcl-2 to prevent apoptosis can be differentially regulated." in: Cell death and differentiation, Vol. 3, Issue 1, pp. 113-8, 2006 (PubMed).

Background publications Cheng, Levine, Boise, Thompson, Hardwick: "Bax-independent inhibition of apoptosis by Bcl-XL." in: Nature, Vol. 379, Issue 6565, pp. 554-6, 1996 (PubMed).

Rajah, Bhala, Nunn, Peehl, Cohen: "7S nerve growth factor is an insulin-like growth factor-binding protein protease." in: Endocrinology, Vol. 137, Issue 7, pp. 2676-82, 1996 (PubMed).

Chittenden, Harrington, OConnor, Flemington, Lutz, Evan, Guild: "Induction of apoptosis by the Bcl-2 homologue Bak." in: Nature, Vol. 374, Issue 6524, pp. 733-6, 1995 (PubMed).

Kiefer, Brauer, Powers, Wu, Umansky, Tomei, Barr: "Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak." in: Nature, Vol. 374, Issue 6524, pp. 736-9, 1995 (PubMed).

Yin, Oltvai, Korsmeyer: "BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax." in: Nature, Vol. 369, Issue 6478, pp. 321-3, 1994 (PubMed).

Cohen: "Programmed cell death in the immune system." in: Advances in immunology, Vol. 50, pp. 55-85, 1991 (PubMed).