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Details for Product No. ABIN135680

Integrin alpha-L (ITGAL) antibody

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Antigen
Synonyms CD11A, LFA-1, LFA1A, (p180), Cd11a, LFA-1A, Ly-15, Ly-21, CD11a
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Pubmed 4 references available
Catalog no. ABIN135680
Quantity 0.1 mg
Price
124.30 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Clone 38
Isotype IgG2a
Characteristics The antibody detects: Human CD11a (LFA-1)
Purification Purified
Purity Purified
Alternative Name CD11a/LFA-1a
Background CD11a, also known as leukocyte function-associated antigen-1 (LFA-1), represents the 180 kDa integrin L subunit which combines with the CD18 2 integrin subunit to form the L2 integrin heterodimer. It is expressed on lymphocytes, granulocytes, monocytes, and macrophages and is upregulated on activated T cells. CD11a/LFA-1 mediates adhesion of lymphocytes to vascular endothelium and is involved in costimulation.
Application Notes Working Dilution:
FACS: 1 µg/10^6 cells
Representative data are included in this product insert.

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Comment

Blocking studies, cell adhesion, cytotoxicity

Sample Volume 1 mL
Restrictions For Research Use only
Buffer Product is supplied as 0.1 mg purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2.
Preservative Azide free
Handling Advice Each reagent is stable for the period shown on the bottle label if stored as directed.
Storage 4 °C
Springer: "Adhesion receptors of the immune system." in: Nature, Vol. 346, Issue 6283, pp. 425-34, 1990 (PubMed).

Dransfield, Hogg: "Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits." in: The EMBO journal, Vol. 8, Issue 12, pp. 3759-65, 1990 (PubMed).

Springer: "Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm." in: Cell, Vol. 76, Issue 2, pp. 301-14, 1994 (PubMed).

Lub, van Kooyk, Figdor: "Ins and outs of LFA-1." in: Immunology today, Vol. 16, Issue 10, pp. 479-83, 1995 (PubMed).

Alternatives for antigen "Integrin alpha-L (ITGAL)", type "Antibodies"
Hosts (261), (125), (25), (4)
Reactivities (206), (155), (46), (35), (27), (23), (11), (6), (2), (1), (1), (1)
Applications (357), (122), (55), (40), (40), (28), (22), (18), (15), (10), (9), (9), (8), (6), (3), (2), (1), (1), (1)
Conjugates (80), (52), (47), (15), (7), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (2), (1)
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