ZFPM2 antibody (AA 701-800)

Catalog No. ABIN1386622

Product Details anti-ZFPM2 Antibody

Target: ZFPM2 (Zinc Finger Protein, FOG Family Member 2 (ZFPM2))

Binding Specificity: AA 701-800

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZFPM2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FOG2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for ZFPM2

Target: ZFPM2 (Zinc Finger Protein, FOG Family Member 2 (ZFPM2))

Alternative Name: FOG2 (ZFPM2 Products)

Synonyms: B330005D23Rik antibody, FOG-2 antibody, FOG2 antibody, DIH3 antibody, ZC2HC11B antibody, ZNF89B antibody, hFOG-2 antibody, FOG-A antibody, fog2a antibody, zgc:152696 antibody, zinc finger protein, multitype 2 antibody, zinc finger protein, FOG family member 2 antibody, zinc finger protein, FOG family member 2a antibody, Zfpm2 antibody, ZFPM2 antibody, zfpm2a antibody

Background:

Synonyms: FOG-2, FOG2_HUMAN, Friend of GATA 2, Friend of GATA protein 2, Friend of GATA2 , hFOG-2 , ZFPM2, Zinc finger protein 89B, Zinc finger protein M2, Zinc finger protein multitype 2 , Zinc finger protein ZFPM2.

Background: The FOG family of transcriptional cofactors, including FOG (friend of GATA-1) and FOG-2, are zinc finger proteins that interact with the GATA family of transcriptional regulators. FOG/GATA-1 complexes are required for erythroid and megakaryocyte maturation, and they promote differentiation during embryonic development. These complexes involve the association between multiple zinc fingers on the FOG proteins and the N-terminal zinc finger of GATA proteins. While FOG cooperatively regulates GATA-1 induced transcription, FOG-2 is able to both positively and negatively influence GATA mediated transcription. FOG-2 is predominantly expressed in heart, neurons and gonads, and it preferentially participates in the regulation of GATA-3, GATA-4 and GATA-6. In cardiomyocytes and fibroblasts, FOG-2 inhibits GATA-4 transcriptional activity, yet FOG-2 restores GATA-1 mediated transcription in erythroid cultures deficient in FOG, suggesting that the observed effects of FOG-2 are context specific and vary between cellular systems.