NOVA1 antibody (AA 411-510) (Alexa Fluor 350)

Catalog No. ABIN1390593

Product Details anti-NOVA1 Antibody (Alexa Fluor 350)

Target: NOVA1 (Neuro-Oncological Ventral Antigen 1 (NOVA1))

Binding Specificity: AA 411-510

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOVA1 antibody is conjugated to Alexa Fluor 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Cow,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NOVA1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NOVA1

Target: NOVA1 (Neuro-Oncological Ventral Antigen 1 (NOVA1))

Alternative Name: Nova1 (NOVA1 Products)

Synonyms: Nova-1 antibody, NOVA1 antibody, si:ch211-222c22.9 antibody, 9430099M15Rik antibody, G630039L02 antibody, NOVA alternative splicing regulator 1 antibody, neuro-oncological ventral antigen 1 L homeolog antibody, neuro-oncological ventral antigen 1 antibody, RNA-binding protein Nova-1 antibody, lipid A export ATP-binding/permease protein antibody, NOVA1 antibody, Nova1 antibody, nova1.L antibody, nova1 antibody, LOC790874 antibody, novA1 antibody

Background:

Synonyms: Neuro oncological ventral antigen 1, Neuro-oncological ventral antigen 1, NOVA 1, Nova-1, Nova1, NOVA1_HUMAN, Onconeural ventral antigen 1, Paraneoplastic Ri antigen, RNA binding protein Nova 1, RNA-binding protein Nova-1, Ventral neuron specic protein 1, Ventral neuron-specic protein 1.

Background: Nova-1 and Nova-2 are members of a superfamily of protein regulators of RNA metabolism in neurons. Both are nuclear RNA binding proteins with K homology motifs, conserved protein sequences which bind to RNA (1,2). Nova proteins, normally sequestered in the central nervous system, are expressed by systemic tumors in patients with the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia (POMA) (3,4). Nova-1 is expressed in the hindbrain and ventral spinal cord and Nova-2 is expressed in the neocortex and hippocampus (4). Nova-1 is necessary for regulating neuron-specific alternative splicing of the glycine receptor Alpha2 pre-mRNA (5).

UniProt: P51513