CDH18 antibody (AA 301-400) (HRP)

Catalog No. ABIN1407002

Product Details anti-CDH18 Antibody (HRP)

Target: CDH18 (Cadherin 18, Type 2 (CDH18))

Binding Specificity: AA 301-400

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDH18 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CDH18

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CDH18

Target: CDH18 (Cadherin 18, Type 2 (CDH18))

Alternative Name: CDH18 (CDH18 Products)

Synonyms: B230220E17Rik antibody, Cdh14l antibody, CDH14 antibody, CDH14L antibody, CDH24 antibody, cadherin 18 antibody, Cdh18 antibody, CDH18 antibody

Background:

Synonyms: CAD18_HUMAN, Cadherin 14, Cadherin14, Cadherin 18, Cadherin18, Cadherin 18, type 2, Cadherin-14, Cadherin-18, CDH14, CDH14L, CDH18, CDH24, EY CADHERIN.

Background: The cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding events that are critical to the maintenance of cell structure and morphogenesis. EY-cadherin, also known as CDH18 (cadherin 18), CDH14 (cadherin 14), CDH24 or CDH14L, is a 790 amino acid single-pass type I membrane protein that contains five cadherin domains. One of several members of the cadherin superfamily, EY-cadherin functions as a type II classical cadherin that is expressed specifically in the central nervous system (CNS), where it plays a role in cell-cell binding events. Specifically, EY-cadherin is thought to be involved in axon guidance and outgrowth, as well as synaptic adhesion within the CNS. EY-cadherin contains a highly conserved C-terminal domain characteristic of all cadherins, but lacks the HAV cell adhesion sequence that is specific to type I cadherins. The gene encoding EY-cadherin is located within a region on chromosome five that is commonly deleted in carcinomas, implicating EY-cadherin as a potential tumor suppressor.

Pathways: Cell-Cell Junction Organization