NAB2 antibody (Cy3)

Catalog No. ABIN1408335

Product Details anti-NAB2 Antibody (Cy3)

Target: NAB2 (NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) (NAB2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NAB2 antibody is conjugated to Cy3

Application: Western Blotting (WB)

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NAB2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NAB2

Target: NAB2 (NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) (NAB2))

Alternative Name: Nab2/Mader (NAB2 Products)

Synonyms: mader antibody, AI451907 antibody, MADER antibody, NGFI-A binding protein 2 (EGR1 binding protein 2) antibody, Ngfi-A binding protein 2 antibody, NGFI-A binding protein 2 antibody, nab2 antibody, Nab2 antibody, NAB2 antibody

Background:

Synonyms: EGR 1 binding protein 2, EGR-1-binding protein 2, EGR1 binding protein 2, MADER, Melanoma associated delayed early response protein, Melanoma-associated delayed early response protein, MGC75085, Nab 2, nab2, NAB2_HUMAN, NGFI A binding protein 2 EGR1 binding protein 2, NGFI A binding protein 2, NGFI-A-binding protein 2, Protein MADER.

Background: Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2 are corepressors of EGF-1/NGFI-A. Both NAB1 and NAB2 contain an amino terminal NAB conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy terminal NCD2 domain, which is responsible for the repressor function of NAB proteins. NAB2 is principally localized in the nucleus and may play a role in the downregulation of NGFI-A activity as well as in controlling fundamental processes such as cell division, differentiation and apoptosis. NAB2 localizes to chromosome 12q13.3-14.1, a region that is rearranged in several solid tumors, lipomas, and liposarcomas.