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Amyloid beta (A4) Precursor Protein (APP) (AA 18-38) antibody

Details for Product No. ABIN1449275, Supplier: Login to see
Antigen
  • APP
  • APP-like
  • APPL
  • Abeta
  • BcDNA:GH04413
  • CG7727
  • Dmel\\CG7727
  • EG:65F1.5
  • appl
  • aaa
  • abeta
  • abpp
  • ad1
  • appi
  • ctfgamma
  • cvap
  • pn2
  • AAA
  • ABETA
  • ABPP
  • AD1
  • APPI
  • CTFgamma
  • CVAP
  • PN-II
  • PN2
  • Abpp
  • Adap
  • Ag
  • Cvap
  • E030013M08Rik
  • betaApp
  • app
  • wu:fj34d10
  • wu:fk65e12
  • zgc:85740
Alternatives
anti-Human Amyloid beta (A4) Precursor Protein antibody for Enzyme Immunoassay
Epitope
AA 18-38
122
109
52
35
25
20
19
17
17
15
15
14
14
14
13
11
10
8
8
8
6
6
6
5
5
5
5
5
5
5
5
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
823
308
276
41
11
9
8
8
6
3
2
2
1
1
1
1
Host
Mouse
580
222
50
3
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
48
37
35
17
13
13
13
13
13
13
13
13
12
11
11
2
2
1
Application
Western Blotting (WB)
563
316
231
150
147
75
57
33
29
20
15
10
9
8
6
3
2
2
2
2
1
Supplier
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Immunogen Synthetic peptide corresponding to APP695 (18-38 aa)
Sequence LEVPTDGNAG LLAEPQIAMF C
Clone 3-00E-009
Isotype IgG1
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse
Purification Protein A agarose
Alternative Name Amyloid beta A4 Protein / APP (APP Antibody Abstract)
Background Alzheimer's disease (AD) is the most common form of dementia in the elderly. The neuropathological hallmarks are neurofibrillary tangles and senile plaques. The major protein component of the plaques consists of 39-42 amino acids peptide (ß-amyloid/Aß). Aß occurs in two predominant forms with different COOH-termini, Aß 40 and Aß 42, and overproduction of Aß 42 has been suggested to be the cause of familial earlyonset AD. Aß generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two proteases: ß-secretase and ?-secretase. Recent study suggested that a transmembrane aspartic protease, termed ß-site APP-cleaving enzyme (BACE), functionally acts as the ß-secretase.Synonyms: ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II
Gene ID 351
NCBI Accession NP_000475
UniProt P05067
Research Area Neurology, Alzheimer's Disease
Pathways Caspase Cascade in Apoptosis, EGFR Signaling Pathway
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Reconstitution Restore with 100 μL of distilled water.
Buffer PBS ( pH 7.2), 0.09 % NaN3, 1 % sucrose
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted (in aliquots) at -20 °C.
Supplier Images
Western Blotting (WB) image for anti-Amyloid beta (A4) Precursor Protein (APP) (AA 18-38) antibody (ABIN1449275) anti-Amyloid beta (A4) Precursor Protein (APP) (AA 18-38) antibody
Background publications Gylys, Fein, Yang et al.: "Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence." in: The American journal of pathology, Vol. 165, Issue 5, pp. 1809-17, 2004 (PubMed).

Kang, Lemaire, Unterbeck et al.: "The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor." in: Nature, Vol. 325, Issue 6106, pp. 733-6, 1987 (PubMed).

Golde, Estus, Younkin et al.: "Processing of the amyloid protein precursor to potentially amyloidogenic derivatives." in: Science (New York, N.Y.), Vol. 255, Issue 5045, pp. 728-30, 1992 (PubMed).