Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN1449275

Amyloid beta (A4) Precursor Protein (APP) (AA 18-38) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, Dmel\\CG7727, EG:65F1.5, appl, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp, app, wu:fj34d10 ... show more
Epitope
»Alternatives AA 18-38
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN1449275
Quantity 0.1 mg
Price
346.50 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide corresponding to APP695 (18-38 aa)
Sequence LEVPTDGNAGLLAEPQIAMFC
Clone 3E9
Isotype IgG1
Specificity This antibody reacts with Amyloid Precursor Protein.
Purification Protein A agarose
Alternative Name Amyloid beta A4 protein / APP
Background Alzheimer's disease (AD) is the most common form of dementia in the elderly. The neuropathological hallmarks are neurofibrillary tangles and senile plaques. The major protein component of the plaques consists of 39-42 amino acids peptide (ß-amyloid/Aß). Aß occurs in two predominant forms with different COOH-termini, Aß 40 and Aß 42, and overproduction of Aß 42 has been suggested to be the cause of familial earlyonset AD. Aß generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two proteases: ß-secretase and ?-secretase. Recent study suggested that a transmembrane aspartic protease, termed ß-site APP-cleaving enzyme (BACE), functionally acts as the ß- secretase.
Alternate names: ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II
Gene ID 351
NCBI Accession NP_000475.1
UniProt P05067
Research Area Neurology, Alzheimer's Disease
Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with 100 µL of distilled water.
Buffer PBS (pH 7.2) 0.09% Sodium azide 1% sucrose
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted (in aliquots) at -20°C.
Expiry Date 12 months
Background publications Golde, Estus, Younkin et al.: "Processing of the amyloid protein precursor to potentially amyloidogenic derivatives." in: Science (New York, N.Y.), Vol. 255, Issue 5045, pp. 728-30, 1992 (PubMed).

Kang, Lemaire, Unterbeck et al.: "The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor." in: Nature, Vol. 325, Issue 6106, pp. 733-6, 1987 (PubMed).

Gylys, Fein, Yang et al.: "Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence." in: The American journal of pathology, Vol. 165, Issue 5, pp. 1809-17, 2004 (PubMed).

Alternatives for antigen "Amyloid beta (A4) Precursor Protein (APP)", type "Antibodies"
Hosts (382), (109), (42), (5)
Reactivities (489), (231), (226), (106), (99), (95), (92), (17), (15), (7), (5), (5), (5), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1)
Applications (374), (206), (130), (98), (90), (37), (36), (15), (14), (11), (7), (7), (4), (2), (2), (1), (1), (1), (1)
Conjugates (14), (11), (10), (9), (9), (9), (9), (9), (9), (9), (9), (1), (1)
Epitopes (64), (49), (30), (30), (19), (13), (13), (10), (9), (7), (6), (6), (5), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Beacon