Amyloid beta (A4) Precursor Protein (APP) (AA 18-38) antibody

Details for Product No. ABIN1449275
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Antigen
Synonyms
APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, Dmel\\CG7727, EG:65F1.5, appl, aaa, abeta, abpp, ad1, appi, ctfgamma, cvap, pn2, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Abpp, Adap, ... show more
APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, Dmel\\CG7727, EG:65F1.5, appl, aaa, abeta, abpp, ad1, appi, ctfgamma, cvap, pn2, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp, app, wu:fj34d10, wu:fk65e12, zgc:85740 show less
Epitope
AA 18-38
(98), (86), (33), (33), (25), (13), (13), (10), (10), (9), (9), (7), (7), (7), (6), (5), (5), (5), (5), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(683), (314), (278), (176), (166), (160), (153), (50), (13), (13), (4), (2), (1), (1), (1), (1), (1)
Host
Mouse
(488), (190), (33), (6), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(28), (25), (23), (15), (15), (15), (15), (15), (15), (15), (15), (7), (5), (5), (2), (2)
Application
Western Blotting (WB)
(489), (230), (182), (164), (149), (67), (67), (41), (31), (28), (24), (17), (7), (2), (2), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

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Catalog No. ABIN1449275
357.50 $
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Immunogen Synthetic peptide corresponding to APP695 (18-38 aa)
Sequence LEVPTDGNAG LLAEPQIAMF C
Clone 3-00E-009
Isotype IgG1
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse
Purification Protein A agarose
Alternative Name Amyloid beta A4 Protein / APP
Background Alzheimer's disease (AD) is the most common form of dementia in the elderly. The neuropathological hallmarks are neurofibrillary tangles and senile plaques. The major protein component of the plaques consists of 39-42 amino acids peptide (ß-amyloid/Aß). Aß occurs in two predominant forms with different COOH-termini, Aß 40 and Aß 42, and overproduction of Aß 42 has been suggested to be the cause of familial earlyonset AD. Aß generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two proteases: ß-secretase and ?-secretase. Recent study suggested that a transmembrane aspartic protease, termed ß-site APP-cleaving enzyme (BACE), functionally acts as the ß-secretase.Synonyms: ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II
Gene ID 351
NCBI Accession NP_000475
UniProt P05067
Research Area Neurology, Alzheimer's Disease
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Reconstitution Restore with 100 μL of distilled water.
Buffer PBS ( pH 7.2), 0.09 % NaN3, 1 % sucrose
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted (in aliquots) at -20 °C.
Supplier Images
anti-Amyloid beta (A4) Precursor Protein (APP) (AA 18-38) antibody anti-Amyloid beta (A4) Precursor Protein (APP) (AA 18-38) antibody
Background publications Golde, Estus, Younkin et al.: "Processing of the amyloid protein precursor to potentially amyloidogenic derivatives." in: Science (New York, N.Y.), Vol. 255, Issue 5045, pp. 728-30, 1992 (PubMed).

Kang, Lemaire, Unterbeck et al.: "The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor." in: Nature, Vol. 325, Issue 6106, pp. 733-6, 1987 (PubMed).

Gylys, Fein, Yang et al.: "Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence." in: The American journal of pathology, Vol. 165, Issue 5, pp. 1809-17, 2004 (PubMed).

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