KACL antibody, PILAR antibody, UNQ5792 antibody, CLEC2A antibody, C-type lectin domain family 2 member A antibody, CLEC2A antibody, LOC100847268 antibody, LOC101102719 antibody
Background
CLEC2A (C-type lectin domain family 2 member A), also known as PILAR (proliferation-induced lymphocyte-associated receptor) is involved in modulating T-cell expansion. It is a 32 kDa single-pass type II membrane protein that contains one C-type lectin domain in its extracellular region and belongs to the CTL/CTLD superfamily. CLEC2A is mainly expressed in skin and highly expressed in CD8(+), B lymphocytes and naive CD4(+) T cells. Manipulation of CLEC2A signaling may be important for treatment of autoimmune diseases and cancer.Synonyms: C-type lectin domain family 2 member A, KACL, Keratinocyte-associated C-type lectin, PILAR, Proliferation-induced lymphocyte-associated receptor, UNQ579