RIMS2 antibody (Middle Region)

Catalog No. ABIN1449962

Product Details anti-RIMS2 Antibody

Target: RIMS2 (Regulating Synaptic Membrane Exocytosis 2 (RIMS2))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RIMS2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid synthetic peptide near the center of Human RIM2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for RIMS2

Target: RIMS2 (Regulating Synaptic Membrane Exocytosis 2 (RIMS2))

Alternative Name: RIMS2 (RIMS2 Products)

Synonyms: OBOE antibody, RAB3IP3 antibody, RIM2 antibody, 2810036I15Rik antibody, AW048769 antibody, Rab3ip2 antibody, Rim2(+40A) antibody, Rim2(+44A) antibody, Rim2(+4A) antibody, Serg2 antibody, Syt3-rs antibody, mKIAA0751 antibody, Nim2 antibody, Rim2 antibody, RIMS2 antibody, MGC159469 antibody, rims2 antibody, zgc:73064 antibody, drs antibody, drsp antibody, mema antibody, np-a antibody, pinin antibody, pnn antibody, pnn-a antibody, pnn-b antibody, sdk3 antibody, regulating synaptic membrane exocytosis 2 antibody, regulating synaptic membrane exocytosis 2a antibody, pinin, desmosome associated protein S homeolog antibody, RIMS2 antibody, Rims2 antibody, rims2a antibody, pnn.S antibody

Background: Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release, synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.Synonyms: KIAA0751, RAB3IP3, RIM 2, RIM2, Rab-3-interacting molecule 2, Rab-3-interacting protein 3, Regulating synaptic membrane exocytosis protein 2

Gene ID: 9699

NCBI Accession: NP_001093587

Pathways: Hormone Transport, Synaptic Vesicle Exocytosis