You are viewing an incomplete version of our website. Please click to reload the website as full version.

CARD14 antibody (Caspase Recruitment Domain Family, Member 14) (C-Term)

Details for Product anti-CARD14 Antibody No. ABIN1449966, Supplier: Log in to see
Antigen
  • Bimp2
  • BIMP2
  • CARMA2
  • PRP
  • PSORS2
  • PSS1
Epitope
C-Term
7
4
3
2
2
2
2
1
1
1
1
1
Reactivity
Human
47
26
22
Host
Rabbit
39
7
3
Clonality
Polyclonal
Conjugate
This CARD14 antibody is un-conjugated
2
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
21
19
12
10
7
4
2
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Immunogen 14 amino acid synthetic peptide near the carboxy terminus of Human CARMA2
Isotype IgG
Purification Affinity Chromatography purified via peptide column
Alternative Name CARD14 / CARMA2 (CARD14 Antibody Abstract)
Background CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA2 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kB activation. When expressed in cells, this protein activated NF-kB and induced the phosphorylation of BCL10 Alternative splicing of CARMA2 results in isoforms that possess differential effects on NF-kB activation and endoplasmic reticulum stress-induced cell death.Synonyms: CARD-containing MAGUK protein 2, Caspase recruitment domain-containing protein 14
Gene ID 79092
NCBI Accession NP_077015
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Scudiero, Zotti, Ferravante, Vessichelli, Vito, Stilo: "Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-κB activation and endoplasmic reticulum stress-induced cell death." in: Journal of cellular physiology, Vol. 226, Issue 12, pp. 3121-31, 2011 (PubMed).

Gaide, Martinon, Micheau, Bonnet, Thome, Tschopp: "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation." in: FEBS letters, Vol. 496, Issue 2-3, pp. 121-7, 2001 (PubMed).

Bertin, Wang, Guo, Jacobson, Poyet, Srinivasula, Merriam, DiStefano, Alnemri: "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B." in: The Journal of biological chemistry, Vol. 276, Issue 15, pp. 11877-82, 2001 (PubMed).

Fanning, Anderson: "Protein modules as organizers of membrane structure." in: Current opinion in cell biology, Vol. 11, Issue 4, pp. 432-9, 1999 (PubMed).