APBA1 antibody (N-Term)

Catalog No. ABIN1450013

The Rabbit Polyclonal anti-APBA1 antibody is suitable to detect APBA1 in samples from Human, Mouse and Rat. It has been validated for WB, IF and EIA.

Quick Overview for APBA1 antibody (N-Term) (ABIN1450013)

Target: APBA1 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APBA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-APBA1 Antibody

Binding Specificity: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid synthetic peptide near the amino terminus of Human APBA1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for APBA1

Target: APBA1 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1))

Alternative Name: APBA1 / MINT1

Background: The Amyloid beta 4 (A4) precursor protein-binding family A member 1 (APBA1) is a member of the X11 protein family and a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). APBA1 stabilizes APP and inhibits production of proteolytic APP fragments including the Abeta peptide that is deposited in the brains of Alzheimer's disease patients. It is thought to be involved in signal transduction processes and is a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. APBA1 can also bind to CASK, a multidomain scaffolding protein involved in brain development and synapse formation.Synonyms: Adapter protein X11alpha, Amyloid beta A4 precursor protein-binding family A member 1, Neuron-specific X11 protein, Neuronal Munc18-1-interacting protein 1

Molecular Weight: 92 kDa

Gene ID: 320

NCBI Accession: NP_001154

Pathways: Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport