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RAPGEF4 antibody (N-Term)
RAPGEF4
Reactivity: Human, Mouse, Rat
WB, IHC (p)
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-RAPGEF4 Antibody
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Target
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RAPGEF4
(Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4))
Binding Specificity
All epitopes for RAPGEF4 antibodies
N-Term
Reactivity
All reactivities for RAPGEF4 antibodies
Human, Mouse, Rat
Host
All hosts for RAPGEF4 antibodies
Rabbit
Clonality
All clonalities for RAPGEF4 antibodies
Polyclonal
Conjugate
All conjugates for RAPGEF4 antibodies
This RAPGEF4 antibody is un-conjugated
Application
All applications for RAPGEF4 antibodies
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Cross-Reactivity (Details)
Species reactivity (tested):Human, Mouse, Rat
Purification
Affinity chromatography purified via peptide column
Immunogen
15 amino acid synthetic peptide near the amino terminus of human RAPGEF4 / EPAC2
Isotype
IgG
Top Product
Discover our top product RAPGEF4 Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
1.0 mg/mL
Buffer
PBS containing 0.02 % Sodium Azide as preservative
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for RAPGEF4
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Target
RAPGEF4
(Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4))
Alternative Name
RAPGEF4 (RAPGEF4 Products )
Synonyms
RAPGEF4 antibody, CAMP-GEFII antibody, CGEF2 antibody, EPAC2 antibody, Nbla00496 antibody, 1300003D15Rik antibody, 5730402K07Rik antibody, 6330581N18Rik antibody, EPAC 2 antibody, Epac-2 antibody, Epac2 antibody, mKIAA4040 antibody, CAMPS antibody, Cgef2 antibody, Rap guanine nucleotide exchange factor 4 antibody, rap guanine nucleotide exchange factor 4 antibody, Rap guanine nucleotide exchange factor (GEF) 4 antibody, RAPGEF4 antibody, LOC579050 antibody, LOC100551109 antibody, PTRG_05798 antibody, Rapgef4 antibody
Background
EPAC2, also known as Rap guanine nuclear exchange factor 4 (RAPGEF4) and cAMPGEF-II, is belongs to a family of cyclic adenosine monophosphate (cAMP) binding proteins with guanine nucleotide exchange factor. Like the related protein EPAC1, EPAC2 signaling plays a role in numerous cellular processes such as integrin-mediated cell adhesion, muscle contraction, learning and memory, cell proliferation, and inflammation. Recent evidence suggests that EPAC2 induces synapse remodeling and depression, with mutations in its gene being found in patients with autism.Synonyms: CGEF2, EPAC 2, EPAC2, Exchange factor directly activated by cAMP 2, Exchange protein directly activated by cAMP 2, Rap guanine nucleotide exchange factor 4, cAMP-GEFII, cAMP-regulated guanine nucleotide exchange factor II
Gene ID
11069
NCBI Accession
NP_008954
Pathways
Hormone Transport , Smooth Muscle Cell Migration
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