OPTN antibody (AA 71-96)

Catalog No. ABIN1538582

Product Details anti-OPTN Antibody

Target: OPTN (Optineurin (OPTN))

Binding Specificity: AA 71-96

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OPTN antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This OPTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-96 amino acids from the Central region of human OPTN.

Clone: RB21453

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: OPTN Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for OPTN

Target: OPTN (Optineurin (OPTN))

Alternative Name: OPTN (OPTN Products)

Synonyms: nrp antibody, fip2 antibody, hip7 antibody, hypl antibody, glc1e antibody, tfiiia-intp antibody, ALS12 antibody, FIP2 antibody, GLC1E antibody, HIP7 antibody, HYPL antibody, NRP antibody, TFIIIA-INTP antibody, Fip2 antibody, 4930441O07Rik antibody, fj52f04 antibody, si:ch211-240l19.3 antibody, wu:fj52f04 antibody, zgc:66386 antibody, zgc:77868 antibody, optineurin antibody, optineurin L homeolog antibody, OPTN antibody, optn antibody, Optn antibody, optn.L antibody

Background: This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

Molecular Weight: 65922

Gene ID: 10133

NCBI Accession: NP_001008212, NP_001008213, NP_001008214, NP_068815

UniProt: Q96CV9

Pathways: M Phase