This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This ARAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-93 amino acids from the N-terminal region of human ARAP2.
CENTD1 antibody, PARX antibody, Centd1 antibody, Gm148 antibody, mKIAA0580 antibody, ARAP2 antibody, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 antibody, arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 antibody, ARAP2 antibody, Arap2 antibody, LOC100567363 antibody
Background
The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics.