GLTSCR2 antibody (AA 401-478) (HRP)
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- Target See all GLTSCR2 products
- GLTSCR2 (Glioma Tumor Suppressor Candidate Region Gene 2 (GLTSCR2))
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Binding Specificity
- AA 401-478
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Reactivity
- Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This GLTSCR2 antibody is conjugated to HRP
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Cross-Reactivity
- Mouse
- Predicted Reactivity
- Human,Rat,Dog,Cow,Sheep,Pig,Horse
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human GLTSCR2/PICT1
- Isotype
- IgG
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- Application Notes
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handling Advice
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- GLTSCR2 (Glioma Tumor Suppressor Candidate Region Gene 2 (GLTSCR2))
- Alternative Name
- GLTSCR2/PICT1 (GLTSCR2 Products)
- Synonyms
- GLTSCR2 antibody, pict1 antibody, pict-1 antibody, MGC115044 antibody, PICT-1 antibody, PICT1 antibody, 5330430H08Rik antibody, 9430097C02Rik antibody, AU041936 antibody, AW536441 antibody, R74911 antibody, NOP53 ribosome biogenesis factor antibody, NOP53 ribosome biogenesis factor L homeolog antibody, Nop53 antibody, NOP53 antibody, nop53 antibody, nop53.L antibody
- Background
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Synonyms: Glioma tumor suppressor candidate region gene 2 protein, GLTSCR2, GSCR2_HUMAN, p60, PICT1, protein interacting with carboxyl terminus 1.
Background: The tumor suppressor PTEN plays an essential role in regulating signaling pathways involved in cell growth and apoptosis and is inactivated in a wide variety of tumors. Protein interacting with PTEN carboxyl terminus 1 (PICT-1), also designated p60 or Glioma tumor suppressor candidate region gene 2 protein, binds to the C-terminus of PTEN and regulates its turnover. Five Ser/Thr residues within the C-terminal segment of PTEN, including Ser-380, are phosphorylated upon binding of PTEN to PICT-1 and may contribute to the stabilization of PTEN. PICT-1 is localized to the nucleus and/or nucleolus and is highly expressed in pancreas and heart, but can also be detected in liver, skeletal muscle, placenta and kidney. PICT-1 also interacts with herpes simplex virus 1 regulatory proteins ICP22 and ICP0. The tumor suppressor GLTSCR2 gene, which encodes PICT-1, is located in a 150-kb minimal common deletion region for human gliomas, especially oligodendrogliomas, and maps to human chromosome 19q13.3.
- Gene ID
- 29997
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