DR4 antibody (C-Term)

Catalog No. ABIN1733768

Product Details anti-DR4 Antibody

Target: DR4 (Drought-Repressed 4 Protein (DR4))

Binding Specificity: AA 427-445, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DR4 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Specificity: Reacts with the C-terminus part of human DR4.

Purification: Purified

Immunogen: Peptide corresponding to aa 427-445 at the C-terminus of human DR4 (accession no. ACC51226)

Isotype: IgG

Application Details

Application Notes: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
ICC(10 μg/mL) WB(1 μg/mL)

Positive control: HeLa cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Dilute in PBS or medium which is identical to that used in the assay system.

Storage: -20 °C

Storage Comment: Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DR4

Target: DR4 (Drought-Repressed 4 Protein (DR4))

Alternative Name: DR4 (DR4 Products)

Synonyms: APO2 antibody, CD261 antibody, DR4 antibody, TRAILR-1 antibody, TRAILR1 antibody, TNF receptor superfamily member 10a antibody, TNFRSF10A antibody

Background: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain-containing receptors, TNFR1 and Fas. Another cell death receptor was recently identified and designated DR4. The ligand for DR4 has been designated TRAIL and is a new member of the TNF family. Therefore, DR4 is also called TRAIL receptor-1. DR4 is expressed in most human tissues including spleen, peripheral blood, small intestine, and thymus. Like TNFR1, Fas and DR3, DR4 mediates TRAIL-induced apoptosis and NF-kB activation in many tissues and cells.

Tumor necrosis factor receptor superfamily member 10A Death receptor 4 TNF-related apoptosis-inducing ligand receptor 1, TRAIL receptor 1, TRAIL-R1 CD_antigen: CD261 Gene name: TNFRSF10A, APO2, DR4, TRAILR1

UniProt: O00220

Pathways: Apoptosis, Positive Regulation of Endopeptidase Activity