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Details for Product No. ABIN182375

Transcriptional Adaptor 3 (TADA3) (Middle Region) antibody

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Antigen
Synonyms ADA3, NGG1, STAF54, TADA3L, hADA3, Tada3l, 1110004B19Rik, AI987856, fa03f04, tada3, wu:fa03f04, zgc:63596
Epitope
»Alternatives Middle Region
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Xenopus laevis, Zebrafish (Danio rerio), Human, Chicken
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN182375
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-TADA3L antibody: synthetic peptide directed towards the middle region of human TADA3L
Sequence ASVEPYCADITSEEVRTLEELLKPPEDEAEHYKIPPLGKH YSQRWAQEDL
Predicted Reactivity Zebrafish : 78%
Characteristics This is a rabbit polyclonal antibody against TADA3L. It was validated on Western Blot and immunohistochemistry. We manufacture rabbit polyclonal antibodies on a large scale of high throughput manner. Our antibodies are peptide based and protein family oriented.
Purification Affinity Purified
Alternative Name TADA3L
Background Adaptor proteins are usually required for transcriptional activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter.TADA3L is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis.Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least four alternatively spliced variants have been found for this gene, but the full-length nature of some variants has not been determined.
Molecular Weight 49kDa
Gene ID 10474
NCBI Accession NP_006345, NM_006354
UniProt O75528
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-TADA3L antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Rual, Venkatesan, Hao et al.: "Towards a proteome-scale map of the human protein-protein interaction network." in: Nature, Vol. 437, Issue 7062, pp. 1173-8, 2005 (PubMed).

Shamanin, Sekaric, Androphy: "hAda3 degradation by papillomavirus type 16 E6 correlates with abrogation of the p14ARF-p53 pathway and efficient immortalization of human mammary epithelial cells." in: Journal of virology, Vol. 82, Issue 8, pp. 3912-20, 2008 (PubMed).

Alternatives for antigen "Transcriptional Adaptor 3 (TADA3)", type "Antibodies"
Hosts (19), (7)
Reactivities (26), (6), (6), (3), (3), (3), (3), (3)
Applications (25), (13), (6), (3), (3), (3)
Conjugates (1), (1), (1)
Epitopes (6), (2), (2), (2), (2), (2), (1), (1)
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