RUVBL2 antibody (N-Term)

Catalog No. ABIN182548

This Rabbit Polyclonal antibody specifically detects RUVBL2 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio) and Saccharomyces cerevisiae.

Quick Overview for RUVBL2 antibody (N-Term) (ABIN182548)

Target: RUVBL2 (RuvB-Like 2 (E. Coli) (RUVBL2))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio), Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RUVBL2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-RUVBL2 Antibody

Binding Specificity: N-Term

Sequence: IERIGAHSHI RGLGLDDALE PRQASQGMVG QLAARRAAGV VLEMIREGKI

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 79%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against RUVBL2. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RUVBL2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 463 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RUVBL2

Target: RUVBL2 (RuvB-Like 2 (E. Coli) (RUVBL2))

Alternative Name: RUVBL2

Background: RuvB-Like 2 (48- kDa TATA box-binding protein-interacting protein, Reptin 52, RUVBL2) is the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this protein has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.
Alias Symbols: RVB2, TIH2, ECP51, TIP48, CGI-46, INO80J, REPTIN, TIP49B
Protein Interaction Partner: CCDC103, LNX1, RUVBL1, UBC, DPCD, HUWE1, VCP, SUMO2, RPAP3, MDM2, RPA3, RPA2, RPA1, SUZ12, EED, RNF2, BMI1, CDKN2A, ASNA1, PPP6R3, PLA2G4A, PARK2, FBXO6, TARDBP, YWHAQ, PPP6R2, EXOSC10, BAG3, POLR2E, UPF1, SMG1, RBM8A, TTI1, PAN2, TBP, CTNNB1, STOM, RUVBL
Protein Size: 463

Molecular Weight: 51 kDa

Gene ID: 10856

NCBI Accession: NM_006666, NP_006657

UniProt: Q9Y230

Pathways: Telomere Maintenance