WHSC1 antibody (N-Term)

Catalog No. ABIN182817

Cited in 1 publication. The Rabbit Polyclonal anti-WHSC1 antibody (ABIN182817) specifically detects WHSC1 in WB. The antibody is reactive with Human, Mouse, Rat, Dog, Guinea Pig, Horse and Rabbit samples.

Quick Overview for WHSC1 antibody (N-Term) (ABIN182817)

Target: WHSC1 (Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1))

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WHSC1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-WHSC1 Antibody

Binding Specificity: N-Term

Purpose: NSD2 Antibody - N-terminal region

Sequence: KYNVGDLVWS KVSGYPWWPC MVSADPLLHS YTKLKGQKKS ARQYHVQFFG

Predicted Reactivity: Dog: 93%, Guinea Pig: 88%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 76%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against WHSC1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human WHSC1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8115936

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-WHSC1 antibody (ABIN182817)

Li, Yin, Okamoto, Mushlin, Balgley, Lee, Yuan, Ikejiri, Glasker, Vortmeyer, Oldfield, Weil, Zhuang: "Identification of a novel proliferation-related protein, WHSC1 4a, in human gliomas." in: Neuro-oncology, Vol. 10, Issue 1, pp. 45-51, (2008) (PubMed).

Target Details for WHSC1

Target: WHSC1 (Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1))

Alternative Name: NSD2

Background:

Background Information: This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4,14)(p16.3,q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.

Gene Name: nuclear receptor binding SET domain protein 2

Alternative Symbols: WHS, TRX5, KMT3F, KMT3G, MMSET, WHSC1, REIIBP

Protein Name: histone-lysine N-methyltransferase NSD2

Molecular Weight: 88kDa

Gene ID: 7468

NCBI Accession: NP_055734

UniProt: O96031

Pathways: SARS-CoV-2 Protein Interactome