Fas (TNFRSF6)-Associated Via Death Domain (FADD) (C-Term) antibody

Details for Product No. ABIN184143
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Antigen
Synonyms MORT1, Mort1/FADD, Mort1, TNFRSF6
Epitope
C-Term
(34), (34), (18), (15), (13), (10), (9), (7), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(162), (73), (34), (12), (4), (3), (1)
Host
Rabbit
(163), (56), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (7), (7), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(162), (98), (57), (40), (28), (19), (14), (8), (5), (5), (4), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN184143
289.00 $
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Immunogen Synthetic peptide directed towards the C terminal of human FADD
Sequence AHLVGALRSC QMNLVADLVQ EVQQARDLQN RSGAMSPMSW NSDASTSEAS
Predicted Reactivity Human : 100 %
Characteristics This is a rabbit polyclonal antibody against FADD. It was validated on Western Blot and immunohistochemistry.
Purification Affinity Purified
Alternative Name FADD
Background The protein encoded by FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade.
Molecular Weight 23 kDa
Gene ID 8772
NCBI Accession NM_003824, NP_003815
UniProt Q13158
Research Area Cancer, Apoptosis/Necrosis
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 208 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Product cited in: Thomas, Henson, Reed et al.: "Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD." in: The Journal of biological chemistry, Vol. 279, Issue 31, pp. 32780-5, 2004 (PubMed).

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