Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (C-Term) antibody

Details for Product No. ABIN184156
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Antigen
Synonyms GITR, TNFRSF18, AITR, Gitr, CD357, GITR-D
Epitope
C-Term
(4), (3), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(69), (49), (13)
Host
Rabbit
(58), (23), (19)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (9), (8), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(65), (30), (29), (11), (10), (7), (4), (4), (2), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN184156
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Immunogen Synthetic peptide directed towards the C terminal of human TNFRSF18
Sequence LRSQCMWPRE TQLLLEVPPS TEDARSCQFP EEERGERSAE EKGRLGDLWV
Predicted Reactivity Human : 100 %
Characteristics This is a rabbit polyclonal antibody against TNFRSF18. It was validated on Western Blot and immunohistochemistry.
Purification Affinity Purified
Alternative Name TNFRSF18
Background The protein encoded by TNFRSF18 is a member of the TNF-receptor superfamily. This receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death.
Molecular Weight 26 kDa
Gene ID 8784
NCBI Accession NM_004195, NP_004186
UniProt Q9Y5U5
Research Area Immunology, Adaptive Immunity, Growth Factors, Innate Immunity, Cytokines
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 241 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (C-Term) antibody WB Suggested Anti-TNFRSF18 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Hela cell lysate
Background publications Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

Validation Images
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