TNFRSF18 antibody (AA 266-162)

Catalog No. ABIN7092879

Product Details anti-TNFRSF18 Antibody

Target: TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))

Binding Specificity: AA 266-162

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TNFRSF18 antibody is un-conjugated

Application: Flow Cytometry (FACS), ELISA

Purification: Purified from cell culture supernatant by affinity chromatography

Immunogen: Recombinant human GITR (Gln266-Pro162) (ABIN6961091) produced by using human HEK293 cells

Clone: DM78

Isotype: IgG

Application Details

Application Notes: ELISA 1/5000-10000,Flow Cyt  1/100

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.,0.1 % Procline 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details for TNFRSF18

Target: TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))

Alternative Name: GITR (TNFRSF18 Products)

Synonyms: GITR antibody, TNFRSF18 antibody, AITR antibody, Gitr antibody, CD357 antibody, GITR-D antibody, TNF receptor superfamily member 18 antibody, tumor necrosis factor receptor superfamily, member 18 antibody, TNFRSF18 antibody, Tnfrsf18 antibody

Background: Synonyms:AITR, GITR, TNFRSF18, CD357
Description:This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Molecular Weight: 26.0kDa

Gene ID: 8784

UniProt: Q9Y5U5

Pathways: Cancer Immune Checkpoints