Transcription Factor 12 (TCF12) (N-Term) antibody

Details for Product No. ABIN184293
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Antigen
Synonyms TCF12, CRS3, HEB, HTF4, HsT17266, bHLHb20, A130037E08Rik, ALF1, HEBAlt, HTF-4, ME1, REB, SCBPA, wu:fb74g05, wu:fc43e06, zgc:110341, zgc:85956
Epitope
N-Term
(21), (8), (7), (3), (2), (2), (2), (1), (1), (1)
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus), Chicken, Xenopus laevis, Zebrafish
(57), (26), (26), (2), (1), (1), (1)
Host
Rabbit
(47), (10)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(47), (28), (11), (11), (10), (10), (4), (3), (1)
Pubmed 2 references available
Quantity 50 μg
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Catalog No. ABIN184293
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human TCF12
Sequence QQQRMAAIGT DKELSDLLDF SAMFSPPVNS GKTRPTTLGS SQFSGSGIDE
Cross-Reactivity Cow (Bovine), Chicken, Human, Mouse (Murine), Rat (Rattus)
Predicted Reactivity Bovine : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Zebrafish : 90 %
Purification Affinity Purified
Alternative Name TCF12
Background TCF12 encodes a protein that is a member of the basic helix-loop-helix (bHLH) E-protein family which recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins.The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Molecular Weight 73 kDa
NCBI Accession NM_207036, NP_996919
UniProt Q99081
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes WB Suggested Anti-TCF12 Antibody Titration: 0.06 µg/mL
ELISA Titer: 1:1562500
Positive Control: Human Lung.
Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 706 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage 4 °C
Storage Comment Any unfrozen and/or unused material can be stored at 4 °C for short term use (< 1 week), and should not be re-frozen. For longer periods of storage, store at -24 °C
Supplier Images
anti-Transcription Factor 12 (TCF12) (N-Term) antibody WB Suggested Anti-TCF12 Antibody Titration: 0.06ug/ml
ELISA Titer: 1:1562500
Positive Control: Human Lung
anti-Transcription Factor 12 (TCF12) (N-Term) antibody (2) Host: Rabbit
Target Name: TCF12
Sample Tissue: Human Fetal Brain
Antibody Dilution: 1.0 µg/mL
Background publications Zhang, Kalkum, Yamamura et al.: "E protein silencing by the leukemogenic AML1-ETO fusion protein." in: Science (New York, N.Y.), Vol. 305, Issue 5688, pp. 1286-9, 2004 (PubMed).

General Wissmüller, Kosian, Wolf et al.: "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors." in: Nucleic acids research, Vol. 34, Issue 6, pp. 1735-44, 2006 (PubMed).

Validation Images
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