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Details for Product No. ABIN185303

Abelson Helper Integration Site 1 (AHI1) (N-Term) antibody

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Antigen
Synonyms AHI-1, JBTS3, ORF1, dJ71N10.1, Ahi-1, D10Bwg0629e, 1700015F03Rik, AHI1
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human
Host
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Methode Type Peptide ELISA
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN185303
Quantity 100 µg
Price
261.61 $   Plus shipping costs $45.00
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Immunogen Peptide with sequence PTAESEAKVKTC, from the N Terminus of the protein sequence according to NP_060121.3, NP_001128303.1, NP_001128302.1, NP_001128304.1.
Specificity This antibody is expected to recognise both reported isoforms. Variants ( NP_060121.3, NP_001128303.1, NP_001128302.1) encode the same isofom.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name AHI1 / Jouberin
Background Synonyms: AHI1, AHI-1, DKFZp686J1653, FLJ14023, FLJ20069, JBTS3, ORF1, dJ71N10.1, Abelson helper integration site, jouberin, Ahi-1 isoform I, OTTHUMP00000017263, OTTHUMP00000017264, OTTHUMP00000017265, contatins SH3 and WD40 domains
Gene ID 54806
NCBI Accession NP_060121.3, NP_001128303.1, NP_001128302.1, NP_001128304.1
Application Notes ELISA: antibody detection limit dilution 1:16000.
Western blot: Preliminary experiments gave an approx 22 kDa band in Human Brain lysates after 0.1 µg/mL antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 137 kDa according to NP_060121.3. The 22 kDa band was successfully blocked by incubation with the immunizing peptide.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Product cited in: Zhou, Zhao, Ringrose et al.: "AHI-1 interacts with BCR-ABL and modulates BCR-ABL transforming activity and imatinib response of CML stem/progenitor cells." in: The Journal of experimental medicine, Vol. 205, Issue 11, pp. 2657-71, 2008 (PubMed).

Kennah, Ringrose, Zhou et al.: "Identification of tyrosine kinase, HCK, and tumor suppressor, BIN1, as potential mediators of AHI-1 oncogene in primary and transformed CTCL cells." in: Blood, Vol. 113, Issue 19, pp. 4646-55, 2009 (PubMed).

Jiang, Hanna, Kaouass et al.: "Ahi-1, a novel gene encoding a modular protein with WD40-repeat and SH3 domains, is targeted by the Ahi-1 and Mis-2 provirus integrations." in: Journal of virology, Vol. 76, Issue 18, pp. 9046-59, 2002 (PubMed).

Ferland, Eyaid, Collura et al.: "Abnormal cerebellar development and axonal decussation due to mutations in AHI1 in Joubert syndrome." in: Nature genetics, Vol. 36, Issue 9, pp. 1008-13, 2004 (PubMed).

Dixon-Salazar, Silhavy, Marsh et al.: "Mutations in the AHI1 gene, encoding jouberin, cause Joubert syndrome with cortical polymicrogyria." in: American journal of human genetics, Vol. 75, Issue 6, pp. 979-87, 2004 (PubMed).

Alternatives for antigen "Abelson Helper Integration Site 1 (AHI1)", type "Antibodies"
Hosts (27), (4), (2)
Reactivities (30), (14), (14), (11), (11), (11)
Applications (21), (10), (9), (6), (2), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (3), (2), (1), (1)
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