anti-AHI1 antibody (Abelson Helper Integration Site 1) (N-Term)

Details for Product anti-AHI1 Antibody No. ABIN185303
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Synonyms AHI1, AHI-1, JBTS3, ORF1, dJ71N10.1, 1700015F03Rik, Ahi-1, D10Bwg0629e
(13), (12), (5), (3), (2), (1), (1), (1), (1), (1), (1)
(51), (16), (15)
(37), (13), (7)
This AHI1 antibody is un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Methode Type Peptide ELISA
ELISA, Western Blotting (WB)
(33), (19), (11), (10), (7), (5), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 100 μg
Shipping to United States ( )
Availability Available
Immunogen Peptide with sequence PTAESEAKVKTC, from the N Terminus of the protein sequence according to NP_060121.3, NP_001128303.1, NP_001128302.1, NP_001128304.1.
Specificity This antibody is expected to recognise both reported isoforms. Variants ( NP_060121.3, NP_001128303.1, NP_001128302.1) encode the same isofom.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name AHI1 / Jouberin (AHI1 Antibody Abstract)
Background Synonyms: AHI1, AHI-1, DKFZp686J1653, FLJ14023, FLJ20069, JBTS3, ORF1, dJ71N10.1, Abelson helper integration site, jouberin, Ahi-1 isoform I, OTTHUMP00000017263, OTTHUMP00000017264, OTTHUMP00000017265, contatins SH3 and WD40 domains
Gene ID 54806
NCBI Accession NP_001128303, NP_001128302, NP_060121, NP_001128304
Application Notes ELISA: antibody detection limit dilution 1:16000.
Western blot: Preliminary experiments gave an approx 22 kDa band in Human Brain lysates after 0.1 µg/mL antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 137 kDa according to NP_060121.3. The 22 kDa band was successfully blocked by incubation with the immunizing peptide.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Product cited in: Kennah, Ringrose, Zhou et al.: "Identification of tyrosine kinase, HCK, and tumor suppressor, BIN1, as potential mediators of AHI-1 oncogene in primary and transformed CTCL cells." in: Blood, Vol. 113, Issue 19, pp. 4646-55, 2009 (PubMed).

Zhou, Zhao, Ringrose et al.: "AHI-1 interacts with BCR-ABL and modulates BCR-ABL transforming activity and imatinib response of CML stem/progenitor cells." in: The Journal of experimental medicine, Vol. 205, Issue 11, pp. 2657-71, 2008 (PubMed).

Background publications Dixon-Salazar, Silhavy, Marsh et al.: "Mutations in the AHI1 gene, encoding jouberin, cause Joubert syndrome with cortical polymicrogyria." in: American journal of human genetics, Vol. 75, Issue 6, pp. 979-87, 2004 (PubMed).

Ferland, Eyaid, Collura et al.: "Abnormal cerebellar development and axonal decussation due to mutations in AHI1 in Joubert syndrome." in: Nature genetics, Vol. 36, Issue 9, pp. 1008-13, 2004 (PubMed).

Jiang, Hanna, Kaouass et al.: "Ahi-1, a novel gene encoding a modular protein with WD40-repeat and SH3 domains, is targeted by the Ahi-1 and Mis-2 provirus integrations." in: Journal of virology, Vol. 76, Issue 18, pp. 9046-59, 2002 (PubMed).

Catalog No. ABIN185303
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