Dyslexia Susceptibility 1 Candidate 1 (DYX1C1) (C-Term) antibody

Details for Product No. ABIN185356
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Antigen
Synonyms LOC100220614, DYX1, DYXC1, EKN1, RD, zgc:77853, Edem2, Ekn1, 1700010I24Rik
Epitope
C-Term
(5), (4), (3), (2), (2), (2), (2), (1)
Reactivity
Human
(37), (20), (18), (15), (13), (13), (1), (1), (1)
Host
Goat
(25), (9), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Methode Type Peptide ELISA
Application
ELISA, Western Blotting (WB)
(27), (10), (10), (4), (4), (3), (1), (1)
Pubmed 2 references available
Quantity 100 μg
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Catalog No. ABIN185356
374.27 $
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Immunogen Peptide with sequence C-KIRNVIQGTELKS, from the C Terminus of the protein sequence according to NP_570722.2.
Specificity This antibody is expected to recognise only one of the three reported isoforms (NP_570722.2, isoform a).
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name DYX1C1
Background Synonyms: DYX1C1, DYX1, EKN1, DYXC1, FLJ37882, dyslexia susceptibility 1 candidate 1, MGC70618, RD
Gene ID 161582, 67685
NCBI Accession NP_570722
Application Notes ELISA: antibody detection limit dilution 1:16000.
Western blot: Lysates of COS1 transfected with full length recombinant Human DYX1C1 gave bands at approx 48 kDa after 0.1 µg/mL antibody staining. In addition, a minor band of 24 kDa is detected consistent with observations with N-terminal specific antibodies (unpublished data, LoTurco, Connecticut, USA). The 75 kDa band is visible in the non-transfected COS1 also (first lane) and is therefore non-specific. We call for caution when this product is used in other assays than Western blot. Data kindly provided by Wang and LoTurco, University of Connecticut, USA.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Supplier Images
anti-Dyslexia Susceptibility 1 Candidate 1 (DYX1C1) (C-Term) antibody ABIN185356 staining (0.1µg/ml) of COS1 cell lysates: untransfected (left lane) and transfected with full length recombinant Human DYX1C1 (right lane). Data kindly provided by Wang and LoTurco, University of Connecticut, USA.
Product cited in: Wang, Paramasivam, Thomas et al.: "DYX1C1 functions in neuronal migration in developing neocortex." in: Neuroscience, Vol. 143, Issue 2, pp. 515-22, 2006 (PubMed).

General Taipale, Kaminen, Nopola-Hemmi et al.: "A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 20, pp. 11553-8, 2003 (PubMed).

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