Myeloperoxidase antibody

Catalog No. ABIN187335

Product Details anti-Myeloperoxidase Antibody

Target: Myeloperoxidase (MPO)

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Myeloperoxidase antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: Monoclonal antibody 8F4 reacts with MPO. Species Reactivity: Human and rat. Others not tested.

Sterility: 0.2 μm filtered

Clone: 8F4

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry: The typical starting dilution is 1:10. Immunohistochemistry: (Frozen sections)-The typical starting dilution is 1:10. The optimal dilution for a specific application should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 1 ml containing 100 µg IgG in PBS with 0.1% BSA. The antibody solution was filtered through a 0.2 micron filter.

Storage: 4 °C

Target Details for Myeloperoxidase

Target: Myeloperoxidase (MPO)

Alternative Name: Myeloperoxidase (MPO Products)

Synonyms: mKIAA4033 antibody, MPO antibody, LOC100335032 antibody, POX2' antibody, XPOX2' antibody, mpo antibody, mpo-A antibody, pmr-1 antibody, pmr1 antibody, pox2 antibody, xpox2 antibody, myeloperoxidase antibody, myeloperoxidase L homeolog antibody, MPO antibody, Mpo antibody, LOC100335032 antibody, mpo.L antibody

Background: Myeloperoxidase (MPO) is a glycoprotein with an alpha2beta2 heteromultimer expressed in all cells of the myeloid lineage. MPO is abundantly present in azurophilic granules of polymorphonuclear neutrophils. It is an important enzyme used during phagocytic lysis of engulfed foreign particles which takes part in the defense of the organism through production of hypochlorous acid (HOCl), a potent oxidant. MPO is rapidly released by activated polymorphonuclear neutrophils. Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer, Alzheimer's disease and multiple sclerosis. Autoimmune antibodies to MPO are involved in Wegeners disease. Since the discovery of MPO deficiency, initially regarded as rare and restricted to patients suffering from severe infections, MPO has attracted more clinical attention. In experimental studies antibodies to MPO can be used for various purposes ranging from flow cytometric analysis to detection of polymorphonuclear neutrophils in tissue sections.

Pathways: Chromatin Binding