Desmoglein 1 antibody

Catalog No. ABIN187347

Product Details anti-Desmoglein 1 Antibody

Target: Desmoglein 1 (DSG1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Desmoglein 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: The antibody reacts with the 165 kDa desmoglein 1 protein. Furthermore it does NOT cross-react with desmoglein 2 or desmolglein 3. Clone 27B2 does NOT inhibit the biological activity of desmolein 1. Species Reactivity: Human. Others not tested.

Sterility: 0.2 μm filtered

Clone: 27B2

Isotype: IgG1

Application Details

Application Notes: Immunofluorescence: Use at a 1:10 dilution. Immunohistology: frozen sections Immunoprecipitation: Use at a 1:10 dilution. Western blotting The optimal dilution for a specific application should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 1 mL at 100 µg/mL of 0.2 µm filtered antibody solution in PBS, containing 0.02% sodium azide and 0.1% protein stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for Desmoglein 1

Target: Desmoglein 1 (DSG1)

Alternative Name: Desmoglein-1 (DSG1 Products)

Synonyms: CDHF4 antibody, DG1 antibody, DSG antibody, PPKS1 antibody, SPPK1 antibody, DSG-1 antibody, DSG1 antibody, Dsg1b antibody, Dsg1c antibody, desmoglein 1 antibody, desmoglein 4 antibody, DSG1 antibody, DSG4 antibody, Dsg1 antibody

Background: Desmoglein 1 is a member of the desmosomal cadherin family that comprise the desmogleins and desmocollins. Desmosomes are cell-cell junctions in most epithelial cells and serve to link the intermediate filament cytoskeletons of adjacent cells. Within the desmosome the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmolgein 1 is essential to epidermal integrity.

Pathways: Cell-Cell Junction Organization