BAFF antibody

Catalog No. ABIN187404

Product Details anti-BAFF Antibody

Target: BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This BAFF antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Specificity: Recognizes the stalk region present in the membrane-bound form of human BAFF. Species Reactivity: Human, others not tested.

Immunogen: Human sol. BAFF (rec., aa. 83-285)

Clone: Buffy-1

Isotype: IgG2a

Application Details

Application Notes: Flow Cytometry: optimal concentration range is 0.5-5 µg/ml. Western blotting The optimal dilution for a specific application should be determined by the researcher.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/ml. Purity > 95% as determined by SDS-PAGE. The antibody was purified from concentrated hybridoma cell culture supernatant.

Buffer: 100 µg in PBS and 0.02% sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for BAFF

Target: BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))

Alternative Name: CD257 / BAFF (TNFSF13B Products)

Synonyms: BAFF antibody, BLYS antibody, CD257 antibody, DTL antibody, TALL-1 antibody, TALL1 antibody, THANK antibody, TNFSF20 antibody, ZTNF4 antibody, BAFF-R antibody, BAFFR antibody, BROMIX antibody, CD268 antibody, CVID4 antibody, prolixin antibody, TNFSF13B antibody, RGD1561519 antibody, RGD1560810 antibody, BLyS antibody, D8Ertd387e antibody, zTNF4 antibody, 2010006P15Rik antibody, Baffr antibody, Bcmd antibody, Bcmd-1 antibody, Bcmd1 antibody, Lvis22 antibody, zgc:172115 antibody, TNF superfamily member 13b antibody, TNF receptor superfamily member 13C antibody, tumor necrosis factor (ligand) superfamily, member 13b antibody, tumor necrosis factor receptor superfamily, member 13c antibody, tumor necrosis factor superfamily member 13b antibody, TNFSF13B antibody, TNFRSF13C antibody, Tnfsf13b antibody, Tnfrsf13c antibody, tnfsf13b antibody

Background: BAFF (for B-cell activating factor belonging to the TNF family), a new member of the tumor necrosis factor (TNF) family was simultaneously identified by four different laboratories and named BAFF, TALL-1, THANK, zTNF4. It is abundantly expressed in monocytes and macrophages, upregulated by interferon gamma. Endogenous BAFF is processed intracellularly by a protease of the furin family of proprotein convertases. Secreted BAFF acts as a potent B cell growth factor. Recently, two receptors for BAFF have been identified and termed as BCMA and TACI.

Pathways: NF-kappaB Signaling, Production of Molecular Mediator of Immune Response