This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This FXR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids from the N-terminal region of human FXR1.
FXR1
Reactivity: Human
Host: Rabbit
Polyclonal
FITC
Application Notes
WB: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Coffee, Tessier, Woodruff, Broadie: "Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P." in: Disease models & mechanisms, Vol. 3, Issue 7-8, pp. 471-85, (2010) (PubMed).
Darnell, Fraser, Mostovetsky, Darnell: "Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs." in: Human molecular genetics, Vol. 18, Issue 17, pp. 3164-77, (2009) (PubMed).
Purcell, Wray, Stone, Visscher, ODonovan, Sullivan, Sklar: "Common polygenic variation contributes to risk of schizophrenia and bipolar disorder." in: Nature, Vol. 460, Issue 7256, pp. 748-52, (2009) (PubMed).
Davidovic, Sacconi, Bechara, Delplace, Allegra, Desnuelle, Bardoni: "Alteration of expression of muscle specific isoforms of the fragile X related protein 1 (FXR1P) in facioscapulohumeral muscular dystrophy patients." in: Journal of medical genetics, Vol. 45, Issue 10, pp. 679-85, (2008) (PubMed).
Vasudevan, Steitz: "AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2." in: Cell, Vol. 128, Issue 6, pp. 1105-18, (2007) (PubMed).
Target
FXR1
(Fragile X Mental Retardation, Autosomal Homolog 1 (FXR1))
The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.