This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This HBZ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-123 amino acids from the C-terminal region of human HBZ.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
He, Russell: "Effect of zeta-globin substitution on the O2-transport properties of Hb S in vitro and in vivo." in: Biochemical and biophysical research communications, Vol. 325, Issue 4, pp. 1376-82, (2004) (PubMed).
Kidd, Russell, Watmough, Baker, Brittain: "The role of beta chains in the control of the hemoglobin oxygen binding function: chimeric human/mouse proteins, structure, and function." in: Biochemistry, Vol. 40, Issue 51, pp. 15669-75, (2001) (PubMed).
Lau, Kwok, Chui, Wong, Luo, Tang: "Embryonic and fetal globins are expressed in adult erythroid progenitor cells and in erythroid cell cultures." in: Prenatal diagnosis, Vol. 21, Issue 7, pp. 529-39, (2001) (PubMed).
Century, Fenichel, Horowitz: "The concentrations of water, sodium and potassium in the nucleus and cytoplasm of amphibian oocytes." in: Journal of cell science, Vol. 7, Issue 1, pp. 5-13, (1970) (PubMed).
Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'.