Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This LGALS3BP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-412 amino acids from the Central region of human LGALS3BP.
LGALS3BP
Reactivity: Human
WB, IHC, ICC
Host: Rabbit
Polyclonal
unconjugated
Application Notes
WB: 1:2000. WB: 1:2000. IHC-P-Leica: 1:100
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Srirajaskanthan, Caplin, Waugh, Watkins, Meyer, Hsuan, Beaumont: "Identification of Mac-2-binding protein as a putative marker of neuroendocrine tumors from the analysis of cell line secretomes." in: Molecular & cellular proteomics : MCP, Vol. 9, Issue 4, pp. 656-66, (2010) (PubMed).
Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, (2010) (PubMed).
Zambelli, Zuntini, Nardi, Manara, Serra, Landuzzi, Lollini, Ferrari, Alberghini, Llombart-Bosch, Piccolo, Iacobelli, Picci, Scotlandi: "Biological indicators of prognosis in Ewing's sarcoma: an emerging role for lectin galactoside-binding soluble 3 binding protein (LGALS3BP)." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 1, pp. 41-52, (2009) (PubMed).
Lee, Zhang, Shin, Lee, Kim: "Mac-2 binding protein and galectin-3 expression in mucinous tumours of the ovary: an annealing control primer system and immunohistochemical study." in: Pathology, Vol. 41, Issue 3, pp. 229-33, (2009) (PubMed).
Kim, Lee, Sung, Choi, Choi, Kim, Kim, Yu, Hwang, Kim: "Increased serum 90K and Galectin-3 expression are associated with advanced stage and a worse prognosis in diffuse large B-cell lymphomas." in: Acta haematologica, Vol. 120, Issue 4, pp. 211-6, (2009) (PubMed).
Target
LGALS3BP
(Lectin, Galactoside-Binding, Soluble, 3 Binding Protein (LGALS3BP))
90K antibody, BTBD17B antibody, MAC-2-BP antibody, TANGO10B antibody, Ppicap antibody, CyCAP antibody, MAC-2BP antibody, Tango10b antibody, lgals3bp antibody, zgc:136780 antibody, MAC2BP antibody, Mac-2 BP antibody, zgc:77059 antibody, galectin 3 binding protein antibody, lectin, galactoside-binding, soluble, 3 binding protein antibody, calcium activated nucleotidase 1 antibody, lectin, galactoside-binding, soluble, 3 binding protein a antibody, lectin, galactoside-binding, soluble, 3 binding protein b antibody, LGALS3BP antibody, Lgals3bp antibody, CANT1 antibody, lgals3bpa antibody, lgals3bpb antibody
Background
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1.