ADP-ribosylation factor 5 (ARF5) is a member of the human ARF gene family.These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D.The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily.The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6).The members of each class share a common gene organization.The ARF5 gene spans approximately 3.2kb of genomic DNA and contains six exons and five introns.[provided by RefSeq]