BCL2A1 antibody (C-Term)

Catalog No. ABIN1886941

Product Details anti-BCL2A1 Antibody

Target: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL2A1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide from near the carboxy terminus of human Bfl-1.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for BCL2A1

Target: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Alternative Name: Bfl-1 (BCL2A1 Products)

Synonyms: ACC-1 antibody, ACC-2 antibody, BCL2L5 antibody, BFL1 antibody, GRS antibody, HBPA1 antibody, Bcl2a1d antibody, BCL2A1 antibody, BCL2 related protein A1 antibody, BCL2-related protein A1 antibody, BCL2A1 antibody, Bcl2a1 antibody

Background: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by caspase activation.Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes.One such member is multi-domain antiapoptotic protein Bfl-1, which is overexpressed in stomach and other cancers.Bfl-1 can interact with Bax and suppress apoptosis by inhibiting the release of cytochrome c and caspase-3 activation.It is upregulated in cisplatin-resistant human bladder tumors, suggesting that its expression may be important for cisplatin resistance and inhibition of apoptosis in cancer cells.At least two isoforms of Bfl-1 are known to exist.
Synonyms: Bcl-2-related protein A1, Hemopoietic-specific early response protein

NCBI Accession: NP_004040