RHBDD1 antibody (C-Term)

Catalog No. ABIN1886958

Product Details anti-RHBDD1 Antibody

Target: RHBDD1 (Rhomboid Domain Containing 1 (RHBDD1))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RHBDD1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide from near the carboxy terminus of human RHBDD1.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for RHBDD1

Target: RHBDD1 (Rhomboid Domain Containing 1 (RHBDD1))

Alternative Name: RHBDD1 (RHBDD1 Products)

Synonyms: MGC84665 antibody, RRP4 antibody, 4930418P06Rik antibody, mRHBDD1 antibody, RGD1306477 antibody, rRHBDD1 antibody, rhomboid domain containing 1 antibody, rhomboid domain containing 1 L homeolog antibody, RHBDD1 antibody, rhbdd1.L antibody, rhbdd1 antibody, Rhbdd1 antibody

Background: The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development.RHBDD1 is highly expressed in the testis and is involved in the cleavage of BIK, a proapoptotic member of the Bcl-2 family.Overexpression or suppression by RNAi of RHBDD1 in 293 cells will reduce or enhance BIK-mediated apoptosis, respectively, demonstrating that RHBDD1 modulates BIK-mediated apoptotic activity.In GC-1 cells, a spermatogonia cell line that can differentiate into spermatids within the seminiferous tubules, suppression of RHBDD1 expression by RNAi caused the cells to lose the ability to survive and differentiate in mouse seminiferous tubules, suggesting that RHBDD1 may be associated with mammalian spermatogenesis.
Synonyms: Rhomboid domain containing 1