KCNK12
Reactivity: Human
WB, ELISA
Host: Rabbit
Polyclonal
APC
Restrictions
For Research Use only
Format
Liquid
Buffer
PBS containing 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice
Avoid freezing and thawing repeatly.
Storage
4 °C/-20 °C
Storage Comment
Store at 4 °C for short term use.Store at -20 °C for long term preservation.
Target
KCNK12
(Potassium Channel, Subfamily K, Member 12 (KCNK12))
KCNK12 antibody, K2p12.1 antibody, THIK-2 antibody, THIK2 antibody, mntk1 antibody, potassium two pore domain channel subfamily K member 12 antibody, potassium channel, subfamily K, member 12 antibody, KCNK12 antibody, Kcnk12 antibody
Background
KCNK13 and KCNK12 (also known as THIK1 and 2) are the first two members of a novel two pore-forming P domains K+ channels subfamily.The pore loop domain, a highly conserved region common to all potassium channels, is involved in determining potassium ion selectivity.Members of this family are all characterized by four transmembrane domains and may function to help influence the resting membrane potential of cells.KCNK12 is expressed mainly in the brain and lung, but also observed in the kidneys, heart and skeletal muscle.KCNK12 is closely related to KCNK13 (58% identity at the amino acid level), but could not yet been functionally expressed in vitro and may require other proteins to become active. Synonyms: Potassium channel subfamily K member 12, Tandem pore domain halothane-inhibited potassium channel 2, THIK2