Activin A Receptor Type IB/ALK-4 antibody (C-Term)

Catalog No. ABIN1886993

Product Details anti-Activin A Receptor Type IB/ALK-4 Antibody

Target: Activin A Receptor Type IB/ALK-4 (ACVR1B) (Activin A Receptor, Type IB (ACVR1B))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Activin A Receptor Type IB/ALK-4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity (Details): At least three isoforms of ACVR1B are known to exist. This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1C.

Purification: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide near the carboxy terminus of the human ACVR1B.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for Activin A Receptor Type IB/ALK-4

Target: Activin A Receptor Type IB/ALK-4 (ACVR1B) (Activin A Receptor, Type IB (ACVR1B))

Alternative Name: ACVR1B (ACVR1B Products)

Synonyms: ACVR1B antibody, alk4 antibody, skr2 antibody, alk-4 antibody, xalk4 antibody, actrib antibody, acvrlk4 antibody, DKFZp469A1614 antibody, 6820432J04 antibody, ActR-IB antibody, ActRIB antibody, Acvrlk4 antibody, Alk4 antibody, SKR2 antibody, ACTRIB antibody, ACVRLK4 antibody, ALK4 antibody, Skr2 antibody, axis antibody, taram-a antibody, tarama antibody, wu:fb75f01 antibody, activin A receptor type 1B antibody, Activin receptor type-1B antibody, activin A receptor, type IB antibody, activin A receptor, type 1B antibody, activin A receptor type 1Ba antibody, ACVR1B antibody, acvr1b antibody, acv1b antibody, Acvr1b antibody, acvr1ba antibody

Background: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins.Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors.ACVR1B, also known as activin receptor-like kinase 4 (ALK4), is a type I receptor for activin and plays major roles in cell differentiation, growth arrest and apoptosis.Like another type I activin receptor ACVR1C, ACVR1B can mediate signaling by ligands such as Nodal, Xnr1, GDF-1/3, activin B and activin AB.In Xenopus embryos, expression of a dominant-negative form of ACVR1B blocked all mesoderm-inducing ligands, while expression of a dominant negative ACVR1C only blocked Nodal and Xnr1 signaling, suggesting that the ACVR1B and ACVR1C possess distinct functions.
Synonyms: Activin A receptor type IB, Activin receptor-like kinase 4, Activin receptor type 1B precursor, ACTR-IB, ACVRLK4, ALK4, ALK-4

NCBI Accession: NP_001096