GPR124 antibody (C-Term)

Catalog No. ABIN1887082

Product Details anti-GPR124 Antibody

Target: GPR124 (G Protein-Coupled Receptor 124 (GPR124))

Binding Specificity: C-Term

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPR124 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Purification: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid peptide near the carboxy terminus of the human TEM5.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for GPR124

Target: GPR124 (G Protein-Coupled Receptor 124 (GPR124))

Alternative Name: TEM5 (GPR124 Products)

Synonyms: TEM5 antibody, 8430414O08Rik antibody, 9530074E10Rik antibody, Tem5 antibody, mKIAA1531 antibody, MGC69043 antibody, si:dkey-208c22.2 antibody, GPR124 antibody, adhesion G protein-coupled receptor A2 antibody, adhesion G protein-coupled receptor A2 L homeolog antibody, G-protein coupled receptor 124 antibody, ADGRA2 antibody, Adgra2 antibody, adgra2.L antibody, adgra2 antibody, LOC616111 antibody

Background: Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogensis that are crucial for the growth of solid tumors.TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies.These include TEMs such as TEM1, TEM5, TEM7 and TEM8.TEM5 is a member of the adhesion family of G protein coupled receptors and is localized on the surface of endothelial cells.TEM5 is a seven-pass transmembrane receptor, unlike TEM1, TEM7 and TEM8 which span the membrane once.TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon.Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.
Synonyms: Tumor endothelial marker 5, G protein-coupled receptor 124, GPR124

UniProt: Q96PE1