LASS5 antibody (C-Term)

Catalog No. ABIN1887230

Product Details anti-LASS5 Antibody

Target: LASS5 (LAG1 Homolog, Ceramide Synthase 5 (LASS5))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LASS5 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Cross-Reactivity (Details): Multiple isoforms of LASS5 are known to exist. This antibody may cross-react with the highly homologous LASS6.

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide near the carboxy terminus of the human LASS5.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for LASS5

Target: LASS5 (LAG1 Homolog, Ceramide Synthase 5 (LASS5))

Alternative Name: LASS5 (LASS5 Products)

Synonyms: lass5 antibody, trh4 antibody, LASS5 antibody, Trh4 antibody, 2310081H14Rik antibody, AU045339 antibody, AW544927 antibody, Lass5 antibody, ceramide synthase 5 antibody, ceramide synthase 5 S homeolog antibody, CERS5 antibody, cers5 antibody, cers5.S antibody, Cers5 antibody

Background: The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals.Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation.LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein.Functioning as a dihydro-ceramide synthase, LASS5 is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner.It uses palmitoyl-CoA as an acyl donor and is involved in the synthesis of C14, C16 and C18-ceramide.LASS5 is the most abundantly expressed and predominant ceramide synthase isoform in lung epithelia.Recent studies show that LASS5 partially correct growth and apoptosis.
Synonyms: Longevity Assurance Homolog 5, LAG1, TRH4

NCBI Accession: NP_671723