STEAP1 antibody (C-Term)

Catalog No. ABIN1887239

Product Details anti-STEAP1 Antibody

Target: STEAP1 (Six Transmembrane Epithelial Antigen of The Prostate 1 (STEAP1))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STEAP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity (Details): This STEAP1 antibody does not cross-react with other STEAP proteins.

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide from near the carboxy terminus of human STEAP1.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for STEAP1

Target: STEAP1 (Six Transmembrane Epithelial Antigen of The Prostate 1 (STEAP1))

Alternative Name: STEAP1 (STEAP1 Products)

Synonyms: PRSS24 antibody, STEAP antibody, STEAP1 antibody, 2410007B19Rik antibody, Prss24 antibody, Steap antibody, STEAP family member 1 antibody, six transmembrane epithelial antigen of the prostate 1 antibody, STEAP1 antibody, Steap1 antibody

Background: The six-transmembrane epithelial antigen of prostate 1 (STEAP1) was the first member of a family of metalloreductases identified as cell-surface antigens in prostate tissue.The normal function of STEAP is still uncertain, unlike other members of the STEAP family, STEAP1 does not promote iron or copper reduction or uptake and lacks the FNO-like reductase domain critical for activity.However, its expression is highly increased in multiple cancer cell lines, including prostate, bladder, colon, and ovarian cancers.Supporting this is evidence that STEAP1 peptides can be used to stimulate CD8+ T cells from healthy donors, enabling them to recognize STEAP1-positive human tumor cells, suggesting that STEAP1 may a potential target for cancer immunotherapy.At least three isoforms of STEAP1 are known to exist.
Synonyms: Six transmembrane epithelial antigen of prostate 1, STEAP

Pathways: Transition Metal Ion Homeostasis