LRRTM3 antibody (C-Term)

Catalog No. ABIN1887246

Product Details anti-LRRTM3 Antibody

Target: LRRTM3 (Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3))

Binding Specificity: C-Term

Reactivity: Mouse, Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRTM3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: At least two isoforms of LRRTM3 are known to exist, this antibody will only detect the larger isoform.

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the carboxy terminus of human LRRTM3.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for LRRTM3

Target: LRRTM3 (Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3))

Alternative Name: LRRTM3 (LRRTM3 Products)

Synonyms: 9630044H04Rik antibody, leucine rich repeat transmembrane neuronal 3 antibody, LRRTM3 antibody, lrrtm3 antibody, Lrrtm3 antibody

Background: The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation.Recent evidence suggests that LRRTM3 promotes the processing of amyloid-precursor protein (APP) by the beta-secretase BACE, leading to the proteolytic production of the Abeta42 peptide that is the main component of amyloid plaques.Furthermore, LRRTM3 maps to a region of chromosome 10 linked to both late-onset Alzheimer's disease (AD) and elevated plasma Abeta42 levels, suggesting that LRRTM3 is a functional and positional candidate gene for AD.
Synonyms: Leucine-rich repeat transmembrane neuronal protein 3

NCBI Accession: NP_821079

Pathways: Synaptic Membrane