EI24 antibody (C-Term)

Catalog No. ABIN1887276

Product Details anti-EI24 Antibody

Target: EI24 (Etoposide Induced 2.4 (EI24))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EI24 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: At least two isoforms of EI24 are known to exist, this antibody will only detect the larger isoform.

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the carboxy terminus of human EI24.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for EI24

Target: EI24 (Etoposide Induced 2.4 (EI24))

Alternative Name: EI24 (EI24 Products)

Synonyms: EPG4 antibody, PIG8 antibody, TP53I8 antibody, AA536736 antibody, AI115355 antibody, EI24, autophagy associated transmembrane protein antibody, etoposide induced 2.4 mRNA antibody, EI24 antibody, Ei24 antibody

Background: The etoposide-induced 24 (EI24) protein is an immediate-early induction target of p53-mediated apoptosis and functions as a tumor suppressor.EI24 contains six transmembrane domains and is localized to the endoplasmic reticulum (ER).It binds to Bcl-2 and may contribute to apoptosis by modulating the activity and function of Bcl-2.EI24 is highly mutated in aggressive breast cancers and its loss in breast cancer tissue correlates with tumor invasiveness.Similar findings in invasive cervical carcinoma suggest that EI24 may be a promising therapeutic target in the treatment of invasive cancer.
Synonyms: Etoposide-induced 24, PIG8, EPG4, TP53I8

NCBI Accession: NP_004870