SIP1 antibody (C-Term)

Catalog No. ABIN1887284

Product Details anti-SIP1 Antibody

Target: SIP1 (GEMIN2) (Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the carboxy terminus of human SIP1.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for SIP1

Target: SIP1 (GEMIN2) (Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))

Alternative Name: SIP1 (GEMIN2 Products)

Synonyms: SIP1 antibody, SIP1-delta antibody, 1700012N19Rik antibody, Sip1 antibody, sip1 antibody, sip1-delta antibody, wu:fc52a05 antibody, zgc:110274 antibody, gem nuclear organelle associated protein 2 antibody, gem (nuclear organelle) associated protein 2 antibody, gem nuclear organelle associated protein 2 S homeolog antibody, GEMIN2 antibody, Gemin2 antibody, gemin2.S antibody, gemin2 antibody

Background: SIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins.The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing.SIP1 interacts directly with the SMN and it is required for formation of the SMN complex.A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.However, knockdown of the SIP1 mRNA in motor neurons showed normal motor axons while that of SMN mRNA did show abnormal motor axon outgrowth, indicating that SIP1 may have additional roles outside of the SMN complex.
Synonyms: Survival of motor neuron protein-interacting protein 1, GEMIN2

Pathways: Ribonucleoprotein Complex Subunit Organization, Tube Formation