PLEKHO1 antibody (C-Term)

Catalog No. ABIN1887334

Product Details anti-PLEKHO1 Antibody

Target: PLEKHO1 (Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLEKHO1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Purification: Affinity chromatography purified via peptide column

Immunogen: CKIP1 antibody was raised against an 18 amino acid peptide from near the carboxy terminus of human CKIP1.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for PLEKHO1

Target: PLEKHO1 (Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1))

Alternative Name: CKIP1 (PLEKHO1 Products)

Synonyms: CKIP-1 antibody, OC120 antibody, 2810052M02Rik antibody, Ckip1 antibody, JZA-20 antibody, Jza2 antibody, RGD1311487 antibody, ckip-1 antibody, plekho1 antibody, si:dkey-200h23.2 antibody, pleckstrin homology domain containing O1 antibody, pleckstrin homology domain containing, family O member 1 antibody, pleckstrin homology domain containing, family O member 1a antibody, PLEKHO1 antibody, Plekho1 antibody, plekho1a antibody

Background: CKIP1 was identified through a yeast-two hybrid screening as a protein that would interact with only one of the two catalytic subunits of the casein kinase 2 complex.CKIP1 is a pleckstrin homology domain-containing protein localized within the nucleus and at the plasma membrane that interacts with CK2alpha but not CK2alpha', and is thought to play a role in targeting CK2alpha to a particular cellular location.CKIP1 has been implicated in muscle differentiation and the regulation of cell morphology and actin cytoskeleton.CKIP1 can also interact with other proteins such as ATM, an upstream kinase of p53, and recruit the nuclear ATM to the plasma membrane, suggesting CKIP1 may regulate ATM function through re-localizing ATM.CKIP1 can also form a complex with the kinase AKT, leading to a down-regulation of PI3K/AKT signaling and suppression of tumor growth in vivo.
Synonyms: Casein kinase-2-interacting protein 1, pleckstrin homology domain containing, family O member 1, PLECKHO1

NCBI Accession: NP_057358