BCL2L13 antibody (Center)

Catalog No. ABIN1887535

Product Details anti-BCL2L13 Antibody

Target: BCL2L13 (BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL2L13 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid peptide from near the center of human Bcl-rambo.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for BCL2L13

Target: BCL2L13 (BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13))

Alternative Name: Bcl-rambo (BCL2L13 Products)

Synonyms: si:ch211-238n5.7 antibody, Mil1 antibody, BCL-RAMBO antibody, Bcl2-L-13 antibody, MIL1 antibody, E430016C20Rik antibody, Mil-1 antibody, BCL2 like 13 antibody, BCL2-like 13 (apoptosis facilitator) antibody, BCL2L13 antibody, bcl2l13 antibody, Bcl2l13 antibody

Background: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells.Disruption of this process has been implicated in a variety of diseases such as cancer.Members of the Bcl-2 family are known to be critical regulators of this process.These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains.A novel, widely expressed member termed Bcl-rambo was recently identified.This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2.Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion.This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways.
Synonyms: Bcl-2 like protein 13, Mil1

Pathways: Positive Regulation of Endopeptidase Activity