SRPX antibody (N-Term)

Catalog No. ABIN1887838

Product Details anti-SRPX Antibody

Target: SRPX (Sushi-Repeat Containing Protein, X-Linked (SRPX))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRPX antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogen: 13 amino acid peptide from near the amino terminus of human SRPX1.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for SRPX

Target: SRPX (Sushi-Repeat Containing Protein, X-Linked (SRPX))

Alternative Name: SRPX1 (SRPX Products)

Synonyms: DRS antibody, ETX1 antibody, SRPX1 antibody, drs antibody, drs-1 antibody, drs-2 antibody, mDRS-1 antibody, mDRS-2 antibody, Drs antibody, sushi repeat containing protein, X-linked antibody, sushi-repeat-containing protein antibody, sushi-repeat-containing protein, X-linked antibody, SRPX antibody, Srpx antibody

Background: SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions.Its expression is significantly downregulated in a number cancer cell lines and malignant tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor.SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy.This association of SRPX1 with Rab24 is enhanced during autophagy.
Synonyms: Sushi-repeat-containing protein X-linked, SRPX, DRS, ETX1

NCBI Accession: NP_006298