CCR3 antibody (N-Term)

Catalog No. ABIN1887854

Product Details anti-CCR3 Antibody

Target: CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCR3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Immunoaffinity purified IgG

Immunogen: 14 amino acid peptide from near the amino terminus of human CCR3.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for CCR3

Target: CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))

Alternative Name: CCR3 (CCR3 Products)

Synonyms: CC-CKR-3 antibody, CD193 antibody, CKR3 antibody, CMKBR3 antibody, CC-CKR3 antibody, Cmkbr1l2 antibody, Cmkbr3 antibody, C-C motif chemokine receptor 3 antibody, chemokine (C-C motif) receptor 3 antibody, CCR3 antibody, Ccr3 antibody

Background: Human immunodeficiency virus (HIV) and related virus require coreceptors to infect target cells.Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, CCR8, GPR15, STRL33, and CX3CR1 in the chemokine receptor family were recently identified as HIV coreceptors.CCR5, CXCR4 and CCR3 are the principal receptors for HIV fusion and entry of target cells.CCR3 facilitates infection by a subset of virus.CCR3 and CCR5 promote efficient infection of microglia, the major target cells in the CNS.High levels of CCR3 and CXCR4 expression were found on the neurons from both the central and peripheral nervous systems.The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV infection of microglia.These results indicate CCR3 plays an important role in HIV infection of CNS.
Synonyms: CC chemokine receptor 3, eosinophil eotaxin receptor

NCBI Accession: NP_847899