SKI antibody (N-Term)

Catalog No. ABIN1887862

Product Details anti-SKI Antibody

Target: SKI (SKI Proto-Oncogene (SKI))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SKI antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Purification: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide from near the amino terminus of human Ski.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for SKI

Target: SKI (SKI Proto-Oncogene (SKI))

Alternative Name: Ski (SKI Products)

Synonyms: SGS antibody, SKV antibody, SKI antibody, C-SKI antibody, RGD1565591 antibody, c-ski antibody, 2310012I02Rik antibody, 2610001A11Rik antibody, AA062172 antibody, AA589460 antibody, BC004088 antibody, ski antibody, skv antibody, xski antibody, id:ibd1250 antibody, SKI proto-oncogene antibody, ski sarcoma viral oncogene homolog (avian) antibody, SKI proto-oncogene L homeolog antibody, v-ski avian sarcoma viral oncogene homolog a antibody, SKI antibody, Ski antibody, ski.L antibody, skia antibody

Background: TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis.This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN.Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes.Ski will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.
Synonyms: c-ski, v-ski sarcoma viral oncogene homolog

UniProt: P12755

Pathways: Stem Cell Maintenance, Tube Formation, Skeletal Muscle Fiber Development